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Shanghai Yijing Industrial Co., Ltd.

Pregabalin, Pharmaceuticals, Pharmaceutical Raw Materials manufacturer / supplier in China, offering Pregabalin Powder CAS: 148553-50-8 Pharmaceutical Raw Materials, CAS: 158861-67-7 Ghrp-2 /Pralmorelin for Bodybuilding and Muscle Gaining, Sell High Purity Bodybuilding Oral Clomifene Citrate/Clomid 50-41-9 and so on.

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Supplier Homepage Product Raw chemical materails Pregabalin Powder CAS: 148553-50-8 Pharmaceutical Raw Materials

Pregabalin Powder CAS: 148553-50-8 Pharmaceutical Raw Materials

FOB Price: US $0.5 / ml
Min. Order: 100 ml
Min. Order FOB Price
100 ml US $0.5/ ml
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Port: Shenzhen, China
Production Capacity: 10000kg/Month
Payment Terms: T/T, Western Union, Paypal, Money Gram, Bitcoin

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Basic Info
  • Model NO.: 148553-50-8
  • Customized: Non-Customized
  • State: Powder
  • MOQ: 100ml
  • Appearance: White Powder
  • Molecular Formula: C8h17no2
  • CAS: 148553-50-8
  • Transport Package: Bottle or Drum
  • Origin: Shanghai, China
  • Powder: Yes
  • Certification: GMP, ISO 9001, USP
  • Purity: >99%
  • Product Name: Pregabalin
  • Assay: 99%
  • Capacity: 2000kg
  • Trademark: Yijing
  • Specification: USP/EP/BP
  • HS Code: 3402
Product Description


CAS:148553-50-8
MF:C8H17NO2 
MW:159.23
Assay:99%
Appearance:White powder
Package:1kg/foil bag

Pregabalin is ananticonvulsant drug used for neuropathic pain and as an adjunct therapy for partial seizures with or without secondary generalization in adults. It has also been found effective for generalized anxiety disorder and is (as of 2007) approved for this use in the European Union. It was designed as a more potent successor to gabapentin. Pregabalin is marketed byunder the trade name Lyrica. described in an SEC filing that the drug could be used to treat epilepsy, post-herpetic neuralgia and diabetic peripheral neuropathy, fibromyalgia, et al. Sales reached a record $3.063 billion in 2010. 
Recent studies have shown that pregabalin is effective at treating chronic pain in disorders such as fibromyalgia and spinal cord injury. In June 2007, pregabalin became the first medication approved by the U.S.Food and Drug Administration specifically for the treatment offibromyalgia. 
It is considered to have a low potential for abuse, and a limited dependence liability if misused, and is thus classified as a Schedule Vdrug in the U.S. 
Lyrica is one of four drugs which a subsidiary of in 2009 pleaded guilty to misbranding "with the intent to defraud or mislead". agreed to pay $2.3 billion (£1.4 billion) in settlement, and entered a corporate integrity agreement.illegally promoted the drugs and caused false claims to be submitted to government healthcare programs for uses that were not approved by the U.S. Food and Drug Administration(FDA). 
Pregabalin is available in 25, 50, 75, 100, 150, 200, 225, and 300 mg capsules, and recently a strawberry-flavoured oral solution has been developed, containing 20 mg/mL with an added sweetening agent (sucrose) to mask the chemical's bitter taste. The maximum daily recommended dose for pregabalin is 600 mg. Dosages must be monitored and increases should be based on patient's tolerance.

Indication
Pregabalin is used for the management of neuropathic pain associated with diabetic peripheral neuropathy or spinal cord injury, and postherpetic neuralgia. It is also used as adjunctive therapy for adult patients with partial onset seizures and management of fibromyalgia.
Pharmacodynamics
Pregabalin is a new anticonvulsant drug indicated as an add on therapy for partial onset seizures and for certain types of neuropathic pain. It was designed as a more potent successor to a related drug, gabapentin. Pregabalin binds to the alpha2-delta subunit of the voltage-gated calcium channel in the central nervous system. While pregabalin is a structural derivative of the inhibitory neurotransmitter gamma- aminobutyric acid (GABA), it does not bind directly to GABAA, GABAB, or benzodiazepine receptors, does not augment GABAA responses in cultured neurons, does not alter rat brain GABA concentration or have acute effects on GABA uptake or degradation. However, in cultured neurons prolonged application of pregabalin increases the density of GABA transporter protein and increases the rate of functional GABA transport. Pregabalin does not block sodium channels, is not active at opiate receptors, and does not alter cyclooxygenase enzyme activity. It is inactive at serotonin and dopamine receptors and does not inhibit dopamine, serotonin, or noradrenaline reuptake.

Mechanism of action
Pregabalin binds with high affinity to the alpha2-delta site (an auxiliary subunit of voltage-gated calcium channels) in central nervous system tissues. Although the mechanism of action of pregabalin is unknown, results with genetically modified mice and with compounds structurally related to pregabalin (such as gabapentin) suggest that binding to the alpha2-delta subunit may be involved in pregabalin's antinociceptive and antiseizure effects in animal models. In vitro, pregabalin reduces the calcium-dependent release of several neurotransmitters, possibly by modulation of calcium channel function. Studies also suggest that the descending noradrenergic and serotonergic pathways originating from the brainstem may be involved with the mechanism of pregabalin. Interestingly, although pregabalin is a structural derivative of inhibitory neurotransmitter gamma-aminobutyric acid (GABA), it does not bind directly to GABA or benzodiazepine receptors. The sodium channels, opiate receptors, and cyclooxygenase enzymes are not involved with the mechanism of pregabalin. It is also inactive at serotonin and dopamine receptors and does not inhibit dopamine, serotonin, or noradrenaline reuptake.

Competitive Advantage:
 1 High quality with competitive price: 
1) Standard: Enterprise Standard
2) All Purity≥98%
3) We are manufacturer and can provide high quality products with factory price. 
2 Fast and safe delivery:
1) Parcel can be sent out in 24 hours after payment. Tracking number available
2) Secure and discreet shipment. Various transportation methods for your choice. 
3) Customs pass rate ≥99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring. 
3 We have clients throughout the world:
1) Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire. 
2) Market feedback and goods feedback will be appreciated, meeting customers' requirement is our responsibility. 
3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers. 
 
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PeptidesSpecification
MGF2mg
PEG MGF2mg
CJC-1295 with DAC2mg
CJC-1295 without DAC2mg
PT-14110mg
MT-110mg
MT-210mg
GHRP-25mg
GHRP-210mg
GHRP-6 5mg
GHRP-6 10mg
Ipamorelin2mg
Hexarelin2mg
Sermorelin2mg
Oxytocin2mg
TB5002mg
Pentadecapeptide BPC 1572mg
Triptorelin2mg
Tesamorelin2mg
Gonadorelin2mg
Gonadorelin10mg
DSIP2mg
Selank5mg
Finished steroid oilStrength
Test prop100mg/ml
Test e250mg/ml 300mg/ml
Test cyp250mg/ml 300mg/ml
Test Suspension100mg/ml
Sustanon200mg/ml 250mg/ml 300mg/ml
Deca200mg/ml 250mg/ml
NPP100mg/ml 150mg/ml
Equipoise200mg/ml 250mg/ml 300mg/ml
Tren ace100mg/ml
Tren en100mg/ml 200mg/ml
Masteron100mg/ml 150mg/ml
Primobolone100mg/ml
Supertest 450450mg/ml
Anomass  400400mg/ml
Rippex 225225mg/ml
Tri Tren 180180mg/ml
Tri Test 300300mg/ml
Tri Deca 300300mg/ml
Test Blend 450450mg/ml
Test Blend 500500mg/ml
Nandro Test 225225mg/ml
Mass 500500mg/ml
Cut Depot 400400mg/ml
Tren Test 225225mg/ml
Nandro Test Depot 450450mg/ml
Equi Test 450450mg/ml
Rip Cut 175175mg/ml
Tren Test Depot 450450mg/ml
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