Human Polypeptide Myostatin Hormone Peptide Gdf-8 1mg/Vial
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- Model NO.: Testosterone Cypionate
- Customized: Customized
- Suitable for: Adult
- Purity: >99%
- Molecular Formula: C27h40o3
- Reship Policy: 100%
- Delivery Time: Within 24 Hours After Payment;
- Trademark: Yijing
- Specification: 1mg/vial
- HS Code: 3004319010
- Powder: Yes
- Certification: GMP, HSE, ISO 9001, USP, BP
- State: Powder
- Molecular Weight: 412.61
- Description: White or off-White Crystalline Powder
- Payment Methods: T/ T, Western Union, Bitcoin, Mon
- Delivery Ways: All Express Modes( EMS, DHL, TNT, F
- Transport Package: Suitable Package or According to Your Requirements
- Origin: Shanghai
Myostatin (GDF-8) as a key factor linking muscle mass and bone structure.
Keywords: GDF-8, ActRIIB, bone density, hypertrophy, muscle-bone interactions
GDF-8 Myostatin Description
Myostatin (also known as growth differentiation factor 8, abbreviated GDF-8) is a myokine, a protein produced and released by myocytes that acts on muscle cells' autocrine function to inhibit myogenesis: muscle cell growth and differentiation. In humans it is encoded by the MSTN gene. Myostatin is a secreted growth differentiation factor that is a member of the TGF beta protein family.
Recombinant myostatin (GDF-8) propeptide enhances the repair and regeneration of both muscle and bone in a model of deep penetrant musculoskeletal injury.
GDF- 8 Myostatin Structure and mechanism of action
Human myostatin consists of two identical subunits, each consisting of 109 (NCBI database claims human myostatin is 375 residues long) amino acid residues. Its total molecular weight is 25.0 kDa. The protein is inactive until a protease cleaves the NH2-terminal, or "pro-domain" portion of the molecule, resulting in the active COOH-terminal.
Myostatin also inhibits Akt, a kinase that is sufficient to cause muscle hypertrophy, in part through the activation of protein synthesis. However, Akt is not responsible for all of the observed muscle hyperthrophic effects which are mediated by myostatin inhibition Thus myostatin acts in two ways: by inhibiting muscle differentiation, and by inhibiting Akt-induced protein synthesis.
GDF- 8 Myostatin Application
myostatin has direct effects on the proliferation and differentiation of osteoprogenitor cells, and that myostatin antagonists and inhibitors are likely to enhance both muscle mass and bone strength.antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
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