Oral Powder Sarm S-23 for Bodybuilding
|10-19 20-29 30+|
|FOB Unit Price:||US $30 US $60 US $90|
|Purchase Qty. (g)||FOB Unit Price|
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- Model NO.: S-23
- Customized: Non-Customized
- Suitable for: Elderly, Adult
- Purity: 99.9%
- Transport Package: Carton
- Origin: Shanghai
- Powder: Yes
- Certification: HSE, ISO 9001, USP, BP
- State: Powder
- Trademark: YJ-pharm
- Specification: 1kg/foil bag
- HS Code: 3001
Developed by GTx, S-23 is an orally active nonsteroidal SARM with a very high binding affinity to androgen receptors. This makes it stronger than other popular SARMS like Ostabolic (mk-2866) or Andarine (S-4). Therefore, the main effects of S-23 are increased muscle mass, decreased fat mass, and a decrease in the size of the prostate.
Additionally, in a study done on rats a dose equivalent to 15 milligrams (mg) for a 180lb male was shown to also increase bone mineral density, as well as promote muscle mass growth and fat loss. Hence, S-23 is versatile in that it can be used for bulking and for cutting.
A 2009 study performed on rats showed potential for S-23 to be used as a male contraceptive. In this study, six rats were given a dose of 0.1 mg per day for 10 weeks. As a result, both LH (Luteinizing Hormone) and FSH (Follicle-Stimulating Hormone) levels decreased. These effects were statistically significant, since four of the six rats had no sperm in the testis. What's more, none of the rats was able to impregnate a female rat during mating trials. However, this contraceptive effect was temporary - after just 100 days from last dose the infertility was reversed, and there was a 100% pregnancy rate.
The main side effect of S-23 use is the suppression of natural testosterone production. This is what gives it potential as a male contraceptive, and also makes it very different from other SARMS. While ostarine (ostabolic), andarine (s4), and Anabolicum (LGD) may cause a mild shut down, S-23 is extremely suppressive. Consequently, this will be a major factor in deciding whether to use this SARM or opt for the more widespread choices. Unfortunately, there have not been any human studies, so not much is known on other potential side effects.
Dosages and Cycles
Dosages of S-23 can vary, and they will be very dependent on what the goal is. For instance, if a user were looking for muscle building and fat loss, a dose of 15-25 mgs per day would be appropriate. On the other hand, if someone was looking to use it for the contraceptive effects, a higher dose of around 50 mgs per day would be more effective. Nonetheless, this is not recommended because there have not been studies done on humans to replicate the contraceptive effect shown in rats.
In spite of the fact that after 100 days the rats did recover natural testosterone levels, humans would need to run a full PCT (Post Cycle Therapy). Since S-23 causes severe suppression, I would always recommend the Perfect PCT.
The full name for S23 [structural formula shown below] is (S)-N-(4-cyano-3-trifluoromethyl-phenyl)-3-(3-fluoro,4-chlorophenoxy)-2-hydroxy-2-methyl-propanamide. S23 is closely related to S22, another SARM doing the rounds on the grey market.
How safe is S23? S22 and S23, like ostarine and andarine, were developed by GTx. Companies like GTx are pinning their hopes on SARMs becoming an alternative to hormones like testosterone, so they are searching for a substance that has the desirable characteristics of testosterone, but not the less desirable characteristics.
Supplements containing Hericium erinaceus can be bought online. They usually contain 500 mg extract per capsule. The supplement is used above all as a cerebrogenic - by people looking to improve their mental capacity.
SARMs should boost muscle growth, reduce fat mass and strengthen bones - but not cause prostate enlargement or increase aggression or decrease natural testosterone production.
The search still has a long way to go, but there are already dozens of SARMs circulating in the doping world and the grey supplements market.
How safe is S23? These substances have not been made in the factories of SARMs developers, but in the factories of chemicals manufacturers in Asia. Although most SARMs are patented, these producers ignore the patents and are pushing their products on the global market.
Most of these SARMs have not yet been tested on humans, but only on rats or mice. This is also true for S23.
S23 can be taken orally, but in this experiment the researchers gave male rats daily injections of S23 for 14 days. The doses varied from 0.01 to 1 mg S23 a day. The human equivalent of these doses - for an adult male weighing 80 kg - would be somewhere between 0.5 mg and 50 mg.
The figure below shows that a dose of 0.3 mg S23 [human equivalent: 15 mg] leads to an increase in muscle mass, but that the prostate dimensions decreased.
S23 not only boosted muscle mass, but also reduced fat mass, as you can see in the figure above.
So far, S23 would seem to be good stuff for athletes. This is probably because S23 is an excellent ligand for the androgen receptor. S23 attaches itself to an androgen receptor just as easily as DHT does.
But when the researchers looked at the effect of S23 on the body's own testosterone production, it emerged that S23 probably suppresses this heavily. The SARM definitely reduces the secretion of the hormones LH and FSH.
And S23 halts the production of sperm in the testes. In fact it does this so well that the researchers suspect S23 might be a good candidate for a male contraceptive. If this is the case it would probably have to be part of a cocktail that also contains an estradiol analogue, the researchers discovered. The lab animals lost their libido when they were given S23 on its own, and only recovered this when they were given estradiol benzoate together with the S23.
S-23 has many potential benefits that range from muscle building and fat loss, to being a possible male contraceptive. Even though this SARM may seem very intriguing, it is still in a very early stage of development and study. Thus, I would proceed with caution when considering this compound. Keep in mind that there are other SARMS on the market today, such as ostabolic and testolone, which give similar muscle building and fat loss effects and are much more studied. Besides, other SARMS will also cause much less suppression of natural testosterone production, allowing the user to run a considerably milder and shorter PCT. All in all, I would recommend sticking to the tried and true until more research is done on S-23. In simple terms, stay away from this SARM until we know more.
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