Tudca Trearment of Liver Disorder Powder Tauroursodeoxycholic Acid
|10-19 20-29 30+|
|FOB Unit Price:||US $3 US $2 US $1|
|Purchase Qty. (g)||FOB Unit Price|
|Payment Terms:||T/T, Western Union, Money Gram, Bitcoin|
- Model NO.: 14605-22-2
- Customized: Non-Customized
- Suitable for: Adult
- Purity: >96%
- Mf: C26h45no6s
- MP: 173-175
- Transport Package: as Your Request
- Origin: China
- Powder: Yes
- Certification: ISO 9001
- State: Solid
- CAS: 14605-22-2
- MW: 499.7
- Trademark: Yijing
- Specification: 25kg/drum
- HS Code: 3301
|Appearance||White or off-white crystalline powder||White crystalline powder|
|Solubility||Freely soluble in Methanol |
Sparingly soluble in water.
Practically insoluble in ethyl
acetate and acetone.
|Specific optical rotation||+45.0° ~ +47.0°||+46.1°|
|Sulphate Ash||≤0.1 %||0.04 %|
|Taurine||≤ 0.2%||Not detected|
|Ursodeoxycholic Acid||≤ 0.5%||< 0.5%|
|Total unspecified impurities||≤ 0.5%||Not detected|
|Taurochenodeoxycholic Acid||≤ 1.0%||0.02%|
|Any other impurity||≤ 0.1 %||0.04%|
|Total unspecified impurities||≤ 0.5%||0.05%|
|Heavy metal||≤ 20 ppm||< 20ppm|
|Acetone||≤ 5000ppm||2.9 ppm|
|Ethyl acetate||≤ 5000ppm||Not detected|
|Total plate count||≤ 1000 CFU/g||<10 CFU/g|
|Yeast and mold||≤ 100 CFU/g||<10 CFU/g|
Tauroursodeoxycholic acid/TUDCA CAS:14605-22-2
Tauroursodeoxycholic acid is a bile acid also known as TUDCA formed in the liver by conjugation of deoxycholate with taurine, usually as the sodium salt. TUDCA is able to prevent apoptosis and protect mitochondria from cellular elements that would otherwise interfere with energy production. One of these elements is a protein called Bax. TUDCA plays an important role in preventing Bax from being transported to the mitochondria. Bile acids are steroid acids found predominantly in bile of mammals.
The distinction between different bile acids is minute, depends only on presence or absence of hydroxyl groups on positions 3, 7, and 12. Bile acids are physiological detergents that facilitate excretion, absorption, and transport of fats and sterols in the intestine and liver. Bile acids are also steroidal amphipathic molecules derived from the catabolism of cholesterol. They modulate bile flow and lipid secretion, are essential for the absorption of dietary fats and vitamins, and have been implicated in the regulation of all the key enzymes involved in cholesterol homeostasis. Bile acids recirculate through the liver, bile ducts, small intestine and portal vein to form an enterohepatic circuit. They exist as anions at physiological pH and, consequently, require a carrier for transport across the membranes of the enterohepatic tissues. The unique detergent properties of bile acids are essential for the digestion and intestinal absorption of hydrophobic nutrients.
How to take?
Recommended dosage, active amounts, other details 10-13mg daily has once been shown to improve liver regenesis rates in a clinically ill population, and may be the lowest estimate of an active oral dose. When looking at improving bile salt composition, a dose around 15-20mg/kg bodyweight TUDCA seems best according to one study.Benefits have been seen at 1,750mg daily for muscle and liver insulin sensitivity, which is the highest dose used for treatment of fatty liver disease.
TUDCA has significant protective properties for many organs throughout the human body.It protects skeletal muscles and other organs, particularly the liver, by increasing insulin sensitivity to appropriate levels.TUDCA has shown to do this by protecting endoplasm reticulum from stress.
Insulin resistance plays a large part in health issues related to excess fat.TUDCA is used for many liver healing and immune-improving purposes, and also is used to support a healthy gallbladder.
This dietary supplement may have some powerful neuroprotective properties, and is indicated in the protection of cells from destruction.To protect cells, TUDCA modulates certain cell cycle effector genes.While these signaling pathways have been identified, the full role of TUDCA in cell maintenance is not yet fully understood.
By protecting cells from destruction, TUDCA has proven to be effective in helping eye's maintain cones and rods.This photoreceptor protection can go a long way in promoting healthy vision. TUDCA is also linked to increased antioxidant activity.
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