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Synonyms: (+)-GRISEOFULVIN;GRISEOFULVIN;[2S-TRANS]-7-CHLORO-2,4,6-TRIMETHOXY-6'-METHYLSPIRO[BENZOFURAN-2(3H), 1'(2)-CYCLOHEXANE]-3,4'-DIONE;(2S)-TRANS-7-CHLORO-2',4,6-TRIMETHOXY-6'-METHYLSPIRO(BENZOFURAN-2[3H],1'-CYCLOHEXENE)-3,4'-DIONE;7-CHLORO-2',4,6-TRIMETHOXY-6'-METHYL-, (1'S-TRANS)-SPIRO(BENZOFURAN-2(3H),1'-(2)CYCLOHEXENE)-3,4'-DIONE;(+)-griseofulvi;(2s-trans)-7-chloro-2',4,6-trimethoxy-6'-methylspiro[benzofuran-2(3h),1'-cy;(2s-trans)-xy-6'-methyl
Griseofulvin CAS: 126-07-8
Griseofulvin MF: C17H17ClO6
Griseofulvin MW: 352.77
Griseofulvin EINECS: 204-767-4
Griseofulvin Chemical Properties Crystalline Solid
Usage adrenegic blocker, Ca channel blocker, coronary vasodilator, antiarrhythmic
Usage antifungal, inhibits mitosis in metaphase
Usage Griseofulvin is a spirobenzofuran produced by a number of Penicillium species, first isolated in the 1930s by Raistrick's group. Griseofulvin is a selective antifungal agent used to treat skin infections in animals and humans. Griseofulvin acts by binding to fungal tubulin and inhibiting the mitotic spindle. Griseofulvin's ability to bind to keratin is considered an important aspect of the metabolite's access to dermatophytic fungi. More recently, griseofulvin has become an important phenotypic marker in Penicillium taxonomy.
Usage It is an antifungal drug. It is used both in animal and in humans, to treat rigworm infections of the skin and nails. It is derived from the mold Penicillium griseofulvum
|Characteristics||A yellowish-white,microfine powder||yellowish-white,microfine powder|
|Melting point||220ºC About 220ºC||218.4ºC-219.4ºC|
|Specific optical rotation||+354o~+364o||+356o|
|Identification||Meets the requirements||Meets the requirements|
|Check-up Particles size||Meets the requirements||Meets the requirements|
|Acidity||0.25g consumed 0.02mol/l NaOH not more intensely coloured than reference solution Y4||0.6ml|
|Clarity and colour of solution||The solution is clear and not more intensely coloured than reference solution Y4||Y5~Y6|
|Matter soluble in petroleum spirit||≤0.2%||0.1%|
|Related substances||-Cl:<0.60 -H<0.15||-Cl:0.48-H:0.04|
|Loss on drying||≤1.0%||0.1%|
|Abnormal toxicity||Meets the requirements||Meets the requirements|
|assay(on the anhydrous substance)||97.0%~102.0%||98.3%|
|Conclusion||The above certificate of analysis is in compliance with BP/EP,meets the standard requirements.|
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