Natural Supplements Tudca Tauroursodeoxycholic Acid 14605-22-2 for Liver Disorder
Product Name: Tauroursodeoxycholic Acid
refractive index: 46 ° (C=1, EtOH)
appearance: Off-White Solid
TUDCA is short for tauroursodeoxycholic acid, basically, a metabolite of the prescription drug ursodeoxycholic acid.
Tauroursodeoxycholic Acid, commonly referred to as TUDCA, is a derivative of a secondary bile salt secreted from the liver. When bile salts created by the liver reach the intestines, they can be converted into UDCA by intestinal bacteria and TUDCA is created when a Taurine molecule is added to the structure. Both of these related molecules are known as hydrophilic bile acids.
It is a common constituent of bile acids, and is in high amounts in the bile acids of bears where is has
traditionally been extracted. UDCA is prescribed for the treatment of cholestatic liver disease. While UDCA is great for reversing liver disease, you can't get it without a prescription not to mention, it'll cost you a fortune to get. That's where TUDCA comes in. Because it's a metabolite of UDCA, TUDCA gives you great liver protection.
With TUDCA, you're getting a product that may be just as potent without a prescription or the crazy price of UDCA. So you're thinking, what's the big deal? I can take milk thistle and get the same benefits for cheaper. Not really. Milk thistle helps bile production, but it's no comparison to the mighty TUDCA when you consider this fact: oral supplements of milk thistle just don't absorb well. Compare that with the hundred of studies supporting the effects of ORAL supplementation of TUDCA. So yeah, you can spend less on the milk thistle and throw your money away. Or you can spend a few extra bucks and get the liver supplement that works - TUDCA.
1.Helps protect the liver First, this bile acid acts to restore bile acid transporters. Doing this allows bile to
flow normally via these transporters. Not only that, but it also acts to prevent formation of the toxic steroid
glucuronides in the first place. A 2003 study showed that TUDCA is a noncompetitive inhibitor of steroid
glucuronidation in vivo and in vitro. This means fewer toxic metabolites will be made in the first place! And, TUDCA may also increase the excretion of any glucuronide metabolites that do get formed, so they will not be around long enough in the liver to start down regulating any bile acid transporters.
2.Aids in production of bile
4.Promotes healthy cholesterol levels Ursodeoxycholic acid (udca) is a secondary bile acid in the body. It also helps the digestive track breakdown cholesterol. It is the only FDA approved drug to treat cirrhosis. It has been shown to reduce jaundice and liver enzymes.
5.Protects the eyes The natural form of the bile, most commonly found in bears, has been used in traditional Chinese medicine for thousands of years to treat a variety of ailments and conditions. There is even a 3,000-year-old scroll that mentions it as being a cure for blindness.
|Appearance||White or off-white crystalline powder||White crystalline powder|
|Solubility||Freely soluble in Methanol |
Sparingly soluble in water.
Practically insoluble in ethyl
acetate and acetone.
|Specific optical rotation||+45.0° ~ +47.0°||+46.1°|
|Sulphate Ash||≤0.1 %||0.04 %|
|Taurine||≤ 0.2%||Not detected|
|Ursodeoxycholic Acid||≤ 0.5%||< 0.5%|
|Total unspecified impurities||≤ 0.5%||Not detected|
|Taurochenodeoxycholic Acid||≤ 1.0%||0.02%|
|Any other impurity||≤ 0.1 %||0.04%|
|Total unspecified impurities||≤ 0.5%||0.05%|
|Heavy metal||≤ 20 ppm||< 20ppm|
|Acetone||≤ 5000ppm||2.9 ppm|
|Ethyl acetate||≤ 5000ppm||Not detected|
|Total plate count||≤ 1000 CFU/g||<10 CFU/g|
|Yeast and mold||≤ 100 CFU/g||<10 CFU/g|